该剧讲述安内相因为公司倒闭而不得不带着一家大小住进小舅子尹启相的家里，因此太太尹裕善变得情绪极不稳定，只好在弟弟家帮忙张罗一家大小琐事。 尹裕善的弟弟尹启相和尹智锡，分别为医师和高中体育老师，两人长相不同，个性也不同，自从姐姐一家搬来寄住在他们家里后，从此兄弟俩和姐姐、姐夫及外甥安钟硕、外甥女安水晶天天上演趣味又搞笑的生活故事。
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